If the amount of fat exceeds what the body needs, abnormal fat accumulations may develop in the liver, causing an increase in liver enzymes and inflammation
In addition, you must meet one of the three clinical criteria set by CMS, measured at the time you start GLP-1 therapy: BMI of 35 or higher (and age 18 or older), or BMI of 30 or higher (and age 18 or older), plus one of the following: heart failure with preserved ejection fraction, uncontrolled high blood pressure (systolic above 140 or diastolic above 90 despite treatment with two blood pressure medications), or chronic kidney disease stage 3a or above, or BMI of 27 or higher (and age 18 or older), plus one of the following: prediabetes, a previous heart attack, a previous stroke, or symptomatic peripheral artery disease If you take a GLP-1 for another condition, the Bridge is not for you
Weekend submissions go to the front of the line Monday morning
In addition to GLP-1s now well-known ability to treat diabetes and obesity, Al-Aly and his team found connections between GLP-1 use and reduced risk of substance use disorders, suicidal ideation, seizures, dementia and Alzheimers disease, among many others
Less common side effects Beyond the gastrointestinal basics, tirzepatide can cause other effects that catch some members off guard: Fatigue is reported by a meaningful subset of users, particularly in the early weeks