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It is important to emphasise that there is no official link established between tirzepatide and menstrual disturbances in the approved product literature

Supplementary material The Supplementary Material for this article can be found online at: Glossary apoA1 Apolipoprotein A1 LDGs Low-Density Granulocytes AS atherosclerosis LOX-1 Lectin-like oxidized low-density lipoprotein receptor-1 ASCVD atherosclerotic cardiovascular disease LPS Lipopolysaccharide BAFF B-cell-activating factor MAPKs Mitogen-activated protein kinases CACs circumferential artery cells MDA malondialdehyde CAD coronary artery disease MMF Mycophenolate mofetil cGAS-STING cyclic GMP-AMP synthase - stimulator of interferon genes pathway MMP Matrix Metalloproteinase CPA cyclophosphamide MPO Myeloperoxidase CVDs cardiovascular diseases MyD88 myeloid differentiation factor 88 DMB 3,3-dimethyl-1-butanol NETs Neutrophil Extracellular Traps DNase I Deoxyribonuclease I NF-B Nuclear Factor Kappa B ECM extracellular matrix NOX NADPH Oxidase EPCs endothelial progenitor cells NOS Nitric Oxide Synthase FMO3 flavin monooxygenase 3 Ox mtDNA Oxidized Mitochondrial DNA FMT Fecal Microbiota Transplantation oxLDL Oxidized Low-Density Lipoprotein HCQ hydroxychloroquine PAD Peptidylarginine Deiminase HDL High-Density Lipoprotein PC Phosphatidylcholine HFD high-fat diet pDCs Plasmacytoid Dendritic Cells HGF hepatocyte growth factor PD-L1 programmed death ligand 1 HMGB1 High Mobility Group Box 1 PKM2 pyruvate kinase M2 IAA indole-3-acrylic acid PON1 Paraoxonase 1 I3C Indole-3-carbinol ROS Reactive Oxygen Species ICAM-1 Intercellular Adhesion Molecule-1 SCFAs Short-Chain Fatty Acids ICs immune complexes SLE systemic lupus erythematosus IDO1 indoleamine 2,3-dioxygenase 1 SR-A1 scavenger receptor A1 IFN-I Type I interferons Tang cells CD3+CD31+CXCR4+ angiogenic T-cells TYK2/JAK1 IFNAR-mediated JAK kinase Tfh Follicular helper T-cells iNKT Invariant Natural Killer T-cells Th1 CXCR3+ T helper 1 cells IPA indole-3-propionic acid TJPs Tight Junction Proteins IRF Interferon regulatory factor TLR Toll-like receptors ISGs interferon-stimulated genes TMA Trimethylamine ISRE interferon-stimulated response element TMAO Trimethylamine-N-Oxide JAKi Janus kinase inhibitors VCAM-1 Vascular Cell Adhesion Molecule-1 LBP Lipopolysaccharide Binding Protein VEGF vascular endothelial growth factor LDL low-density lipoprotein VSMC vascular smooth muscle cell

FOXO4-DRI may enhance cell functioning and tissue health by removing these aged cells

Tresiba provides exogenous insulin

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