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RYBELSUS and cardiovascular safety RYBELSUS does not increase the risk of major cardiovascular (CV) events such as heart attack, stroke, or death
Other gastrointestinal effects that may occur on the first day or within the initial week include mild abdominal discomfort, bloating, or changes in bowel habits
That difference is why medical authorities are so cautious
However, if irritability turns into frequent anger, intense frustration, or mood swings that affect relationships and daily activities, it may be a sign of something more serious
Some states require additional testing or licensure steps that add cost
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