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Substance-use screening is handled directly: an opt-out exclusionary block flags current alcohol, opioid, or substance-use disorder, and a separate three-month opiate-history field requires free-text date range, name, dose, and frequency before the patient can advance
I think it also upregulates it or something
its full side-effect profile has not been established by the MHRA or EMA
Notably, limited data were available for people with BMI 40 kg m 2 , the elderly, adolescents and people with overweight (BMI 25 kg m 2 and 25 kg m 2 ), with a treatment duration of at least 48 weeks, which compared OMMs with the specific indication of obesity treatment with either placebo or other OMM
Constipation, diarrhea, stomach ache, and nausea are the most common side effects of semaglutide
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