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Potential Benefits Anabolic signalling (preclinical): Cell and animal studies report increased cell growth and protein synthesis via IGF-1 receptor activation [1]

Increased response to immune checkpoint inhibitors with dietary methionine restriction in a colorectal Cancer model

In the vast majority of cases, acanthosis nigricans is linked to insulin resistance

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Lifelong treatment may be needed when the body is unlikely to regain the ability to absorb enough vitamin B12, such as autoimmune gastritis or the major surgical causes identified by NICE