Consider: Baseline blood pressure and heart rate measurement before starting combination therapy Regular monitoring during dose titration of either medication Prompt evaluation of palpitations, chest pain, or shortness of breath Caution in patients with pre-existing cardiovascular disease , including coronary artery disease, arrhythmias, or uncontrolled hypertension ECG evaluation if indicated by clinical history or symptoms Nutritional adequacy must be maintained
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Therefore, antidiabetic medication decreases blood sugar levels, reduces body weight through a reduction in appetite [94], and lowers glycated hemoglobin (HbA1c), all while having a low risk of causing hypoglycemia [104]