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Lancet 405(10489):15801593 Marso SP, Bain SC, Consoli A et al (2016) Semaglutide and cardiovascular outcomes in patients with type 2 diabetes

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I., Yatsunenko, T., Manary, M

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In receptor-binding studies, tirzepatide demonstrated a high affinity for the GIPR, comparable to that of native GIP, while its affinity for the GLP-1R is approximately 18- to 20-fold weaker than that of native GLP-1 [33]