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Continuous use without cycling can lead to receptor desensitization, diminishing returns, and unknown long-term effects

Co-authors include Jennifer Hwang, DO, Neda Laiteerapong, MD, Elbert Huang, MD and David D

If low levels of B 12 remain for a long time, the condition also can lead to irreversible damage to nerve cells, which can cause the following symptoms: numbness and tingling in the hands and feet difficulty walking muscle weakness irritability memory loss dementia depression psychosis

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In addition, GLP-1s have the potential to impact substance or alcohol use disorder and Prader-Willi syndrome through their effect on satiety hormones