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A majority of type 2 diabetes patients on metformin alone fail to achieve glycemic targets, making the addition of semaglutide a logical next step

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Third, major differences existed between the respective trial protocols

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Clinical Pharmacology & Therapeutics, 57(5), 552-558

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A lower dose that maintains glucose in target range while minimizing GI side effects is the optimal dose, not the maximum dose

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Genetic predisposition

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