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Method Umbrella review methods This umbrella review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is prospectively registered with PROSPERO (CRD42024585231)

In Pennsylvania, a $3.5 billion facility in Fogelsville, announced in January 2026 and beginning construction in 2026, will manufacture tirzepatide and next-generation peptides including retatrutide, with completion expected in 2031

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