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These medicines work by mimicking the action of the naturally occurring hormone GLP-1, which is released from the intestine in response to food intake
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Moreover, britanin, a bioactive terpenoid extracted from Inula lineariifolia , increased intracellular GPX4 and GSH levels and diminished ferroptosis-induced MIR injury via AMPK/GSK3/Nrf2 signaling [90]
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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
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