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Different areas of the body can have slightly varying absorption rates, potentially affecting how the body metabolizes the medication
doi:10.1007/s11011-012-9335-5 Urban KR, Gao WJ
These medications are contraindicated during pregnancy and breastfeeding
It can mean significantly more nausea, vomiting, and GI distress, and in some cases, hypoglycemia in patients who are also managing blood sugar with other medications
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