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In preclinical animal models: wound closure accelerated (50% closure day 5 vs vehicle day 7, full-thickness excisional model), tendon tensile strength improved (+58% at day 14 vs vehicle, Achilles model), gastric lesion index reduced (6878% vs vehicle, ethanol ulcer model), inflammatory cytokines reduced (TNF- 4252%, IL-6 3844%, colitis model), angiogenesis stimulated (CD31+ MVD +44% vs vehicle), and neuroprotection demonstrated (NSS improved, lesion volume 2834%, TBI model)
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Bulletin of Experimental Biology and Medicine, 2018
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