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As the pigment responsible for determining skin color, too much melanin can disrupt the balance of a persons skin tone and leave them with uneven coloring
Gu W, Yan H, Winters KA et al (2009) Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia
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Kidney and liver disease, in some cases
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