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Constipation: Retatrutide vs Other GLP-1 Medications Understanding how constipation on Retatrutide compares to other medications in the class provides useful context

As GLP-1 medications curb appetite and improve insulin sensitivity: Liver Enzymes Trend Down: Enzymes tend to return to normal ranges as liver fat clears

GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals

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