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Similarly, elevated global DNA methylation, Dnmt activity, and 5-methylcytosine but decreased Tet activity and 5-hydroxymethylcytosine were observed in the GSH-deficient hepatocytes and the liver of HFD-fed mice

The mechanisms by which free subunit affects tumor cell growth have not been elucidated, and it is not known whether similar actions of free subunit could influence proliferation of normal or malignant trophoblast cells

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