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According to a report published by the International Diabetes Federation, more than 530 million people are suffering from DM in 2021, and this number is expected to reach 780 million by 2040 [1]

After inflammasome activation, Caspase-1 and Caspase-4/5/11 are activated, which promote the cleavage and maturation of Pro-IL-1 and Pro-IL-18, and cleavage of Gasdermin D (GSDMD), resulting in the GSDMD-N terminal fragment inserting into the cell membrane and forming pores, leading to the leakage of cellular contents and lytic cell death (89, 90)

Short-Term Stability : The inclusion of benzyl alcohol inhibits bacterial growth, extending the usable life of peptide solutions for short-term storage

It occurs due to various factors such as the dosage of the medication, body mass index, metabolism, timing of meals, food choices, and hydration