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Most evidence preclinical

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Further research has revealed that Am-EVs exhibit multifaceted regulatory capacities, simultaneously enhancing glucose metabolism and energy expenditure through activation of both GLP-1 and AMPK signaling pathways while concurrently mitigating local inflammation via TLR2/4-mediated suppression of proinflammatory cytokines and reinforcing intestinal barrier function through upregulated expression of tight junction proteins ZO-2 and CLDN4 [79]

Inherited disorders of folate and cobalamin transport and metabolism (updated chapter in OMMBID)