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Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial
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Standard titration schedule Each increase happens at minimum four-week intervals, though many providers extend to six or eight weeks per step depending on tolerability
Trulicity (dulaglutide) Another GLP-1 agonist, Trulicity, is approved for type 2 diabetes management
Retatrutide is currently under investigation in a global phase 3 clinical trial programme, following promising results from its phase 2 study (NCT04881760) published in the New England Journal of Medicine in 2023
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