[2] Dulaglutide (Trulicity), another once-weekly injectable GLP-1 agonist, demonstrates a somewhat more favourable gastrointestinal tolerability profile in some studies, with nausea reported in approximately 8-12% of patients at lower doses, though rates increase with higher doses (3
doi: 10.1016/j.dsx.2017.09.013 29 Yovera-AldanaMVelasquez-RimachiVHuerta-RosarioAMore-YupanquiMDOsores-FloresMEspinozaRet al
194 of those patients were taking semaglutide versus 516 who were on non-GLP-1 RA medications
Investigation of the Haemodynamic Effects of Exenatide in Healthy Male Subjects
168 Indeed, liver biopsies confirm that the prevalence of clinically significant fibrosis in MASLD and MASH patients is only 20.27% and 35.14%, respectively, 169 with lower proportions in patients with normal or lean body weight, 170 suggesting that antifibrotic treatment may not be necessary for a larger proportion of patients