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Additionally it was noted that in the rats treated with AOD9604, there were increased rates of lipolytic activity, as well as no negative effect on insulin sensitivity which has been seen in animals treated with human growth hormone ( A similar study conducted by Heffernan et

Direct effects on cellular proliferation A genetically engineered murine model of pancreatic intraepithelial neoplasia (PanIN) to PDAC progression ( LSL-Kras G12D ;Pdx1-Cre, KC ) treated with exenatide demonstrated architectural changes of loss of polarity and micropapillary formation following 12 weeks of therapy 18

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