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10.1186/s12944-018-0939-6 83

This caution comes mainly from cosmetic formulators rather than dermatology trials, so it is not a firm rule

MDA forms adducts with TBARS, thiobarbituric acid in particular, with which it forms a 1:2 adduct

A GP or relevant specialist can help assess individual risk, identify potential contraindications, and provide guidance grounded in evidence-based medicine

The benefit of this is that this higher dose can be injected in one shot and the benefits of B12 supplementation may be felt sooner