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The UPS consists of many factors that include E3 ubiquitin ligases, ubiquitin hydrolases, ubiquitin and ubiquitin-like molecules, and the proteasome itself

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In vitro studies have examined the interaction between the CKGGRAKDC targeting motif and white adipose tissue vasculature-associated endothelial cell populations, documenting the phage display-identified peptides selective homing to WAT endothelium and characterising prohibitin and ANXA2 as the receptor basis of this endothelial cell targeting activity [1]