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The bigger picture: semaglutide is not just about weight loss Here is something that gets lost in the conversation about semaglutide and muscle loss
Losing weight reduces leptin, which signals energy deficit, which increases hunger and reduces metabolic rate
This may lead to higher reductions in waist size for men than women when taking a GLP-1, he says
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Retatrutide at 12mg produced approximately 24% weight loss at 48 weeks compared to tirzepatide at 15mg producing approximately 22% at 72 weeks
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