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Given the copper pathways implicated, users with pre-existing copper overload, Wilson disease, or severe liver disease may be at increased risk and should avoid use
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K
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Five participants withdrew or were lost to follow up and two participants experienced protocol deviations
There are no effects on weight or an increased risk of hypoglycemia (in the absence of concomitant treatment with insulin or sulfonylureas) (83)
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