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Safety and evidence level: what is and isnt known In the mouse obesity study, systemic administration of the NNMT inhibitor reduced body weight, white-adipose mass and plasma cholesterol without changing food intake and without any observable adverse effects over the study period
It reduces contamination risk but does not prevent chemical degradation of the peptide
Phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial weight loss in adults with obesity, but the medicine is not yet approved for clinical use in the UK
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