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These include symptoms of pancreatitis (severe abdominal pain radiating to the back, persistent vomiting), allergic reactions (difficulty breathing, facial swelling, severe rash), or signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness)

Newer compounds like retatrutide and combination therapies like cagrilintide with semaglutide (CagriSema) represent the next wave of GLP-1 based interventions for those who have maximized semaglutide monotherapy

59 Compared to human GLP-1 (Figure 1A), the alanine residue at the second position of the N-terminus in GLP-1 RAs and a dual GLP-1/GIP RA (except for liraglutide) has been substituted to prevent metabolism by DPP-4 (Figure 1)

Vegan and vegetarian diets can result in this deficiency