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reported that ferroptosis in hepatocytes and intrahepatic macrophages may be the incentive for early simple steatosis and the progression from NAFLD toward to NASH: hepatocyte ferroptosis precedes apoptosis during the initial stages of NAFLD in model mice, leading to liver damage, immune cell infiltration, and inflammatory response (19)

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Over time, iron accumulation can thus occur in the range of 1g per year (10g per decade)

doi:10.3390/biomedicines9060609 Hsieh MJ, Lee CH, Chueh HY, et al

Development of cagrilintide, a long-acting amylin analogue