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The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)
Higher NAD+ levels activate SIRT1, a master regulator of metabolism, mitochondrial biogenesis, and fat oxidation
There is some risk every time any of us eats fresh produce, and there always has been
American Journal of Epidemiology
A landmark trial of more than 17,600 overweight and obese patients with cardiovascular disease (but not diabetes), found that semaglutide reduced their risk of serious cardiovascular events by 20%
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