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In both the trial-product and treatment-policy estimand analyses, all oral semaglutide groups demonstrated a significantly greater reduction in A1C from baseline when compared with placebo at 26 and 52 weeks

Local injection site reactions are the most common and typically include: Erythema (redness) and warmth at the injection site Swelling or induration (hardening of tissue) Pruritus (itching) or discomfort Bruising or nodule formation in some cases (particularly with exenatide extended-release formulations, where nodules are common and often non-allergic) These reactions usually appear within hours of injection and may resolve spontaneously within a few days

Patients receive their medications through direct delivery to their homes, which helps them stay consistent with their treatment schedule