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In a cPLA2 knockout mouse experiment, the cPLA2-deficient mice appeared to be severely arthritic, implying that cPLA2 is a key player in the pathogenesis of collagen (Hegen et al., P
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These are generally short-lived and can often be prevented or treated with OTC remedies or simple dietary tweaks
Large doses of supplemental CLA can cause increased accumulation of fat in your liver, which is a stepping stone towards metabolic syndrome and diabetes ( Numerous studies in both animals and humans reveal that CLA can drive inflammation, cause insulin resistance and lower good HDL cholesterol ( Keep in mind that many of the relevant animal studies used doses much higher than those people get from supplements
Early changes on the scale may be due to temporary loss of water weight rather than meaningful fat loss
