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The STEP 1 trial extension, published in Diabetes, Obesity and Metabolism , found participants regained two-thirds of their prior weight loss within a year of stopping semaglutide

Growth hormone activates osteoblaststhe cells that build new bone tissue, helping to maintain density and resilience over time

The largest reductions typically occur between months 2 and 6, though continued gradual weight loss can persist for up to 12 months or longer

Cholesterol impact represents the primary concern, with HDL cholesterol often decreasing while LDL may increase

A cardiovascular outcomes trial for Foundayo is ongoing, with results expected in the coming years