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Vitamin B 12 improves transcriptional fidelity during reprogramming To address the role of H3K36me3 during reprogramming, we performed (i) chromatin immunoprecipitation followed by sequencing (ChIPseq) for H3K36me3 and (ii) bulk RNA-seq in MEFs undergoing reprogramming, with and without supplementation of vitamin B 12
and c) irregular dietary patterns), reduced bioavailability (impairment of the intrinsic factor-mediated absorption pathway, often due to the widespread and prolonged use of proton pump inhibitors), and malabsorption syndromes
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Breakthrough BPC-157 in a dose of 500 mcg
