Recent studies suggest that this adaptive regulation can be inhibited by p38 MAPK or blocked by substrate depletion (250)
Lambooy S, Heida A, Joschko C et al (2023) Selective hepatic Cbs knockout aggravates liver damage, endothelial dysfunction and ROS stress in mice fed a western diet
In various cancers, the overactivation of the SUMO pathway is considered a selective advantage in combating stress
To avoid a potential risk of hypercobalaminemia or possible health risks of high-dose dietary supplements, an annual blood test is recommended, after which targeted substitution can be performed
Ganner A, Pfeiffer Z-C, Wingendorf L, Kreis S, Klein M, Walz G, et al