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After de-duplication and screening based on inclusion and exclusion criteria, 123 meta-analyses (115 based on RCTs and 8 based on observational studies) with 464 outcomes were included in this umbrella review (Fig
A once-weekly GLP-1 RA was added to insulin and sitagliptin + other oral agents at index date for 80% of patients
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It is not FDA-approved, and there is no legal or regulated supply available for consumer use
Animal study has also demonstrated that exenatide can promote pancreatic duct hyperplasia, a well-established risk factors for pancreatic cancer (91)
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