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Macronutrients, bile acids (BAs), and microbiota-derived compounds activate many of these GPCRs expressed by GLP-1 expressing cells ( The main G protein-coupled receptors which activation appears to cause the release of GLP-1 are: GPRC6A (74), Tas1R2-Tas2R3(T1R2-T1R3) (75), GPBAR1 (TGR5), and CasR (76, 77) (Table 1)