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PMC11621640
The Lancet (2021) 5
As GH, IGF-1, and insulin continuously modify each others production and actions, a good knowledge of the mechanisms behind these interactions is mandatory
Furthermore, such a retrospective design inherently limits the identification of causal relationships, and unmeasured residual confounding variablessuch as glycemic control, hypoglycemic episodes, familial suicide history, and socioeconomic statusmay persist
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