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Therefore, this issue may not be related to supply and demand
Exenatide increased cerebral glucose metabolic rate (CMRglu) in regions related to glucose homeostasis regulation (frontal, occipital, temporal, parietal lobes, limbic system, insula, and putamen) and food reward (orbitofrontal lobe, thalamus, anterior, and posterior cingulate)
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For example, co-administration of L-carnitine and -lipoic acid did not improve insulin resistance but markedly ameliorated mitochondrial ultrastructure and reduced serum liver enzyme levels, suggesting a preferential correction of mitochondrial injury (32)
Their desirable action on body weight stems from central appetite suppression and retardation of gastric emptying
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