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volatile anesthetics can depolarize mitochondria mildly (which in heart preconditioning is protective, but in immune cells could DAMPsen function) ( 2.1.3.4 Altered macrophage polarization (M1/M2 balance) Macrophages are plastic and can shift phenotypes depending on cues classically activated M1 are pro-inflammatory and microbicidal, whereas alternatively activated M2 are anti-inflammatory and involved in repair ( Figure 2 )
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