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Effect of insulin glargine up-titration vs insulin degludec/Liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: the DUAL V randomized clinical trial
After a meal, insulin secretion is stimulated quickly and considerably in order to maintain plasma glucose concentrations within a narrow physiological range (1)
However, the subcutaneous administration of exendin-4 over the last hour reversed this effect, whereas exendin-4 activated AMPK in animals re-fed for two hours when AMPK activity was markedly inhibited
The subjects had to meet at least 3 of the following components: waist circumference 80 cm in women and 90 cm in men
These metabolic byproducts bind to GPR41 and GPR43 receptors on L-cells, triggering GLP-1 production
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