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[1] [2] Patients with a history of diabetic retinopathy require careful consideration, as the SUSTAIN-6 trial identified a higher incidence of retinopathy complications in the semaglutide group, particularly in those with pre-existing retinopathy and rapid improvement in blood glucose control

Two cohort studies further supported these findings, showing GLP-1 use correlated with reduced prosthetic joint infections, fewer 90-day readmission rates, and reduced 2-year revisions in total knee and hip arthroplasty patients

Another example of the role of food volume to promote intestinal length is in the hyperphagic ob/ob mice, who display significantly longer small intestines 50

Conclusion GLP-1 medications 1) are effective and safe if managed and used properly, including how to eat to fuel your body properly, 2) perform exactly as they are supposed to, and 3) are life-altering

GLP-1s are integral in maintaining energy homeostasis and controlling glucose levels, particularly in individuals with T2D