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See a doctor if you have high B12 and High B12 on a blood test doesnt always require action, but certain combinations warrant prompt evaluation: B12 above 1,000 pg/mL without supplementation or injections Unexplained fatigue, weight loss, abdominal pain, or night sweats alongside elevated B12 Abnormal liver function tests (ALT, AST, bilirubin) or kidney markers (creatinine, GFR) on the same panel Abnormal complete blood count (CBC), especially elevated white blood cells, red blood cells, or platelets B12 levels that are rising over serial measurements without a clear dietary or supplement explanation What to do about high B12 levels There is no specific treatment for high vitamin B12 because the B12 level itself is almost never the problem

Inhibition of Src abolished these effects, confirming its upstream role

Anticancer Drugs 24(9):881888 Dorai T, Dorai B, Pinto JT, Grasso M, Cooper AJL (2020) High levels of glutaminase II pathway enzymes in normal and cancerous prostate suggest a role in glutamine addiction

PMC 523398

If it does in this case, it could open up a can of worms, Sklamberg says