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It belongs to the class of growth hormone-releasing hormones (GHRH) and acts by stimulating the pituitary gland to produce more growth hormone, which can have various positive effects, including lean muscle mass growth, fat metabolism, and overall anti-aging benefits
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However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models
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