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The translation from rat studies involves significant assumptions that may not hold

Location in the Brain GLP-1R are found in key brain regions including the hypothalamus (involved in appetite control), nucleus tractus solitarius (NTS) and area postrema in the hindbrain (regulating satiety and nausea), hippocampus (linked to memory and mood), olfactory bulb, and reward centers like the ventral tegmental area

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Four hundred and thirty (88%) of these patients have conditions for which the drug is a proven benefit , so the increased frequency of injections accounts for most of the observed excess