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In patients with diabetes and albuminuria, the HRs for MACE, HHF, and CKD progression with triple combination therapy were estimated to be 0.65 (95% CI 0.550.76), 0.45 (95% CI 0.340.58), and 0.42 (95% CI 0.310.56), respectively, compared with those for conventional therapy alone (renin-angiotensin system inhibitors and classical risk factor management)
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There are clear reasons why this happens: Appetite increases
Smoking: Smoking generates free radicals, increasing the demand for glutathione and potentially overwhelming its antioxidant capacity
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