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The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig
In the basal state, NF-B dimers (typically p50/p65) are sequestered in the cytoplasm through interaction with inhibitory IB proteins
Silencing the Mfrn2 gene prevents mitochondrial iron overload in MAECs (Wang D
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