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Interestingly however, a more modest effect was seen on GLP-1R endocytosis when -arrestins were ablated, suggesting that the role of desensitization by -arrestins supersedes their role in GLP-1R trafficking
More long-term study is needed
For weight management, Zepbound (which has the same active ingredient) is the FDA-approved option and may offer more support and savings pathways
Forgetting them can reduce their effect
This approach may be particularly relevant for patients who have been on high doses for extended periods or who have concerns about abrupt changes in appetite or glucose control
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