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23 Age-related oxidative stress affects the nervous, endocrine, and immune systems and may create a vicious cycle involving chronic oxidative stress and inflammation, which support each other, and increase age-related morbidity and mortality

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Localized in both mitochondria and cytoplasm, GLUD1 undergoes RNF213-mediated ubiquitination and translocation from mitochondria to the cytoplasm during amino acid deprivation [9]

This makes prevention and early detection of vitamin B12 deficiency incredibly important for the health of older adults

Statistics Statistical analyses were performed using GraphPad Prism 8.0.1 (Dotmatics)