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A 2025 narrative review in MDPI highlights that binge eating is driven by reward-driven overconsumption. For many, the brain becomes hyper-sensitized to food cues, creating a mental tug-of-war

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2 For example, IGF-1R-mediated activation of AKT, in turn, phosphorylates and inhibits pro-apoptotic proteins such as Bad and caspase 9 to promote survival