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World obesity atlas 2022 ( Apovian CM, Aronne LJ, Bessesen DH, et al
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For these five complications, the preferred disutility values (0.263, 0.280, 0.108, 0.164, and 0.090 for each complication, respectively) recommended by the systematic review were used in our base-case analysis, and the lowest value of each complication disutility value range (0.053, 0.177, 0.051, 0.007, and 0.027, respectively) was used in the sensitivity analyses
Important context: oral semaglutide is a GLP-1 receptor agonist only
The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
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